The 2007 Nissan Altima received a Good rating — the highest possible — in the Insurance Institute for Highway Safety's frontal-offset crash test. As of publication, IIHS hasn't subjected the Altima to its side-impact crash test.

All Altimas have standard side-impact airbags for the front seats, side curtain airbags and active head restraints for the front seats. Antilock brakes are not offered on the base 2.5 model but are optional on the 2.5 S and standard on V-6-powered Altimas. Nissan's electronic stability system is optional for V-6 Altimas.

The Altima is one of few family-oriented midsize sedans that can have an optional rearview camera. Part of the Technology Package that includes a navigation system with a 6.5-inch screen and XM satellite radio, the navigation screen displays the camera's image when the car is in Reverse.