The fourth generation Altima was announced at the 2006 New York Auto Show on April 12, 2006. It is the first vehicle to use the smaller Nissan D platform, with a new front and upgraded rear suspension. The wheelbase is 1 inch shorter than the third generation Altima, but interior space is said to be unchanged. The Maxima and Murano will continue on the larger FF-L platform.

The 2007 Altima will use Nissan's VQ35DE 3.5 L V6 engine making 265 horsepower, and will also offer a continuously variable transmission. A 6-speed manual will be standard. The 2007 Altima will sport some more recent innovations in the market including, but not limited to, "Push-button start", Bluetooth capability for cell phones and a parking camera.